One of the most important objectives of this research field is the improvement of the process of bladder tissue building, obtaining an impermeable epithelial surface to obtain well-differentiated UCs and SMCs and a suitable mechanically resilient and compliant ECM. Therefore, the first step usually consists in developing a urinary bladder bioreactor with an efficient process monitoring that recapitulates the in vivo bladder function in a reliable and reproducible way. Bioreactor design criteria must include the possibility of mechanical and nutrient environments control to promote cell proliferation, differentiation, and favorable matrix deposition [41].
Building Design And Construction Vicente 156l
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